Lightbug: Although I think I would agree about the advantageousness of initial positioning of knights towards the centre of the board I wonder whether a fixed setup could lead to an analysis which would result in a forced win for one side, or at least get to a position of significant advantage?

WhisperzQ: That sounds interesting. There could be opening theory for Massacre Chess. Since people are obsessed with fairness in games, trying to find a set setting might be very interesting. There could be openings and theory regarding whether it is better to use minor pieces to attack queens immediately, or is it just as good to protect your queens by attacking minor pieces at the start.

Unfortunately, I don't know what kind of setting would be considered fair. Perhaps some kind of pattern that would be easy to remember like all the knights going through the long diagonals to start with.

Additionally, half the bishops should be on one color and the other. A rook on each file or row some how.