Barbaro (April 29, 2003 – January 29, 2007) was an American thoroughbred that decisively won the 2006 Kentucky Derby but shattered his leg two weeks later, in the 2006 Preakness Stakes, ending his racing career and eventually leading to his death.

On May 20, 2006, Barbaro ran in the Preakness Stakes as a heavy favorite, but, after he false-started, he fractured three bones in and around the ankle of his right hind leg. The injury ruined any chance of a Triple Crown in 2006 and ended his racing career. The next day, he underwent surgery at the New Bolton Center at the University of Pennsylvania for his injuries. In July he developed laminitis in his left rear leg. He had an additional five surgeries, and his prognosis varied as he remained for an extraordinarily long period of time in the equine Intensive Care Unit. While his right leg eventually healed, a final risky surgery on it proved futile because the colt soon developed further laminitis in both front legs. His veterinarians and owners then concluded that he could not be saved, and Barbaro was euthanized on January 29, 2007