Hynde had a daughter, Natalie Rae Hynde, in 1983 with Ray Davies of The Kinks. A cover version of the Davies song "Stop Your Sobbing" had been an early hit for the Pretenders, although Hynde met Davies several years later—a meeting which bloomed into a long-term relationship (although Davies and Hynde never wed). She then married Jim Kerr, lead singer of the band Simple Minds in 1984, and had a daughter, Yasmin Kerr, with him in 1985. They divorced in 1990. She married artist Lucho Brieva in 1997, and lived with him in London until they separated in 2002.

Hynde is set to become a grandmother in April 2011, when her daughter, Yasmin gives birth to twin boys.