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1. e4 e6 2. d4 d5 3. e5 c5 4 c3 tends to be the mainline so white can hold the central pawns.
After 4. Nc3 then 4. ... cxd4 5. Qxd4 Nc6 gives Black a good advantage. Whereas after 4. c3 , 4. ... cxd4 is a bit petty as after 5. cxd4 White has the central pawns and experience tells me that trying to take advantage of the weak looking a5-e1 diagonal is pretty difficult for black.