OK - last try :(

I took out the 20.0 GB Hard Drive out (that i had installed as a slave for storage 2 days ago) to see what would happen then. NOW everything is working fine again. So we are left with the question:

What is causing an extra Hard drive to conflict with my CD player and freeze my PC up every other minute for 1 to 2 seconds.
As far as i know all jumpers are set correct, everything is plugged where it should be. It must be something simple. I can not be the only person on here tryig to get 2 Hard drives and 2 CD drives (1 DVD & 1 CD) on the same machine.